Table 5.

Effect of fluoroquinolone C-8 and C-7-ring substituents on MPC of M. smegmatis

C-7-ring groupMPC (μg/ml)
C-8-HC-8-OMeC-8-F
None6.01.42.0
Methyl5.21.02.2
Dimethyl4.22.03.1
C-3′-Ethyl4.50.91.7
N-Ethyl4.93.15.3
N-Isopropyl191113