Table 5.

MICs of macrolide-lincosamide-streptogramin B antibiotics against MSB strains and transformants

StrainMIC (μg/ml) of compounda:Mutation
ERYCLRAZMJOSTELCLXSTBPEN
BM44190.050.030.100.200.0060.051.560.03None
BM44186.2512.512.56.253.120.05250.03 63KPWRQKGTGREKGTGRAR80
CP10000.030.010.050.050.0030.031.560.01None
BM44403.123.123.123.121.560.03250.01 63KPWRQKGTGREKGTGRAR80
R60.020.050.100.100.0030.021.560.006None
R6 MSB 50>1006.25500.0240.0212.50.01 63KPWRQKTPSRAR74
Bu41100>10012.51000.050.0512.53.12 63KPWRQKTPSRAR74
  • a Fourteen-membered macrolides: erythromycin (ERY) and clarithromycin (CLR); 15-membered macrolide: azithromycin (AZM); 16-membered macrolide: josamycin (JOS); ketolide: telithromycin (TEL); lincosamide: clindamycin (CLX); streptogramin: streptogramin B (STB). PEN, penicillin G.