Table 4.

Substrate specificities of MexAB-OprM, MexCD-OprJ, and MexXY-OprM

TransporterLinkerChannelSubstrates
MexBMexAOprMQuinolones, macrolides, tetracyclines, lincomycin, chloramphenicol, novobiocin, β-lactams except imipenem
MexDMexCOprJQuinolones, macrolides, tetracyclines, lincomycin, chloramphenicol, novobiocin, penicillins except carbenicillin and sulbenicillin, cephems except ceftazidime, flomoxef, meropenem, S-4661
MexYMexXOprMQuinolones, macrolides, tetracyclines, lincomycin, chloramphenicol, aminoglycosides, penicillins except carbenicillin and sulbenicillin, cephems except cefsulodin and ceftazidime, meropenem, S-4661