Parameter^{a} | Estimate (SE) | Estimate^{b} |
---|---|---|

CL/F(liter/kg/day) | 0.733 (0.051) | 0.704 |

V/F(liter/kg) | 20.37 (2.53) | 20.56 |

ω_{CL/F} | 0.15 | 0.16 |

ω_{V/F} | 0.56 | 0.55 |

Residual additive error (ς_{ɛ}[ng/ml]) | 180.4 |

↵a CL/

*F*, clearance divided by the fraction of drug absorbed;*V*/*F*, total apparent volume of distribution divided by the fraction of drug absorbed; ω_{CL/F}and ω_{V/F}, intersubject variability in CL/*F*and*V*/*F*, respectively, modeled with multiplicative error models.↵b Estimates obtained from nonlinear mixed-effects modeling of the 1,000 simulated pharmacokinetic profiles.