Table 1.

Parameters used for simulation of pharmacokinetic profiles

ParameteraEstimate (SE)Estimateb
CL/F(liter/kg/day)0.733 (0.051)0.704
V/F(liter/kg)20.37 (2.53)20.56
ωCL/F 0.150.16
ωV/F 0.560.55
Residual additive error (ςɛ[ng/ml])180.4
  • a CL/F, clearance divided by the fraction of drug absorbed; V/F, total apparent volume of distribution divided by the fraction of drug absorbed; ωCL/F and ωV/F, intersubject variability in CL/F and V/F, respectively, modeled with multiplicative error models.

  • b Estimates obtained from nonlinear mixed-effects modeling of the 1,000 simulated pharmacokinetic profiles.