TABLE 1.

Effects of enterocoated β-lactamase pellets on serum ampicillin concentrations in different test groupsa

Sampling dayMean serum AMP concn (μg/ml)Median serum AMP concn (μg/ml)
AMP + TRBLAMP + plpl + plAMP + TRBLAMP + plpl + pl
00 ± 00 ± 00 ± 0000
121.7 ± 3.522.0 ± 1.70 ± 019.821.90
419.1 ± 2.116.1 ± 1.00 ± 019.416.40
1015.6 ± 1.015.8 ± 1.60 ± 016.415.50
1415.7 ± 2.416.9 ± 2.40 ± 014.914.00
Overall mean18.017.70
Overall median16.816.90
  • a The values for each test group are presented as the mean ± standard error of the mean and the median serum ampicillin concentrations during the treatment period (days 1 to 14). AMP, ampicillin; pl, placebo. The overall difference in the serum ampicillin concentration between the group treated with ampicillin and TRBL and the group treated with ampicillin and placebo is nonsignificant.