TABLE 2.

Posaconazole efficacy against 12 C. albicans isolates in a disseminated candidiasis model

C. albicans strainMIC (mg/liter)ED50 (mg/kg/24 h)24-h AUC/MIC
Total drugFree drug
2-760.0150.251,14011.4
W20.0150.932,51325.1
K10.033.22,64026.4
4120.033.252,66726.7
58100.060.896126.12
14900.061.016606.60
24380.069.362,51725.2
21830.063.741,45014.5
5800.067.332,17221.8
98-170.125.519179.17
98-2340.1212.31,48314.8
98-2100.1213.31,48815.0
Mean ± SD16.9 ± 7.8