TABLE 2.

Effects of enterocoated β-lactamase pellets on jejunum ampicillin concentrations in different test groupsa

Sampling dayMean jejunal AMP concn (μg/ml)Median jejunal AMP concn (μg/ml)
AMP + TRBLAMP + plpl + plAMP + TRBLAMP + plpl + pl
00 ± 00 ± 00 ± 0000
10 ± 061.4 ± 23.10 ± 0087.00
40 ± 08.0 ± 8.00 ± 0000
105.8 ± 5.814.9 ± 6.30 ± 0019.50
140 ± 021.0 ± 9.00 ± 0014.50
Overall mean1.526.30
Overall median015.0b0
  • a The values for each test group are presented as the mean ± standard error of the mean and median jejunum ampicillin concentrations during the treatment period (days 1 to 14). AMP, ampicillin; pl, placebo.

  • b The overall difference in the median jejunum ampicillin concentrations between the group treated with ampicillin and TRBL and the group treated with ampicillin and placebo is significant (P < 0.0001).