TABLE 1.

MICs (μg/ml) of β-lactams for S. oneidensis MR-1, E. coli DH10B harboring recombinant plasmid pSON-1 expressing OXA-54 from S. oneidensis MR-1, E. coli DH10B harboring recombinant plasmid pVT-1 expressing OXA-48 from K. pneumoniae 11978, and the E. coli DH10B reference strain

β-Lactam(s)aMIC (μg/ml) of drug for strain
S. oneidensis MR-1E. coli DH10B (pSON-1) (OXA-54)E. coli DH10B (pVT-1) (OXA-48)bE. coli DH10B
Amoxicillin0.25>512>5124
Amoxicillin + CLA0.25>512>5124
Ticarcillin0.5>512>5124
Ticarcillin + CLA<0.02>512>5124
Piperacillin0.12321282
Piperacillin + TZB<0.02321282
Cephalothin44644
Cefuroxime0.5484
Cefoxitin0.5484
Ceftazidime0.030.120.120.06
Cefotaxime0.010.120.250.06
Cefepime0.010.060.060.06
Cefpirome0.010.250.250.06
Moxalactam0.12220.06
Aztreonam0.030.060.060.12
Imipenem0.12120.06
Meropenem0.050.120.250.06
  • a CLA, clavulanic acid at a fixed concentration of 2 μg/ml; TZB, tazobactam at a fixed concentration of 4 μg/ml.

  • b Data are from reference 16.