TABLE 2.

MICs of β-lactams for K. pneumoniae 11978; K. pneumoniae CIP53153 harboring natural plasmid pA-1; E. coli DH10B harboring recombinant plasmids pVT-1, pVT-2, and pVT-3; E. coli DH10B harboring natural plasmid pA-1 alone or with pA-2; and E. coli DH10B and K. pneumoniae CIP53153 reference strains

β-Lactam(s)aMIC (μg/ml)
K. pneumoniae 11978K. pneumoniae CIP53153 (pA-1) (OXA-48)K. pneumoniae CIP53153E. coli DH10B (pA-1) (OXA-48)E. coli DH10B (pA-1, pA-2) (TEM-1, SHV-2a, OXA-47, OXA-48)E. coli DH10B (pVT-1) (OXA-48)E. coli DH10B (pVT-2) (OXA-47)E. coli DH10B (pVT-3) (SHV-2a)E. coli DH10B
Amoxicillin>512>512>512>512>512>512>512>5124
Amoxicillin + CLA>5121284>512>512>5121281284
Ticarcillin>512>512>512>512>512>512>512>5124
Ticarcillin + CLA>5121282>512>512>5121282564
Piperacillin>512826425612832>5122
Piperacillin + TZB51240.564128128161282
Cephalothin>5120.50.58512642>5124
Cefuroxime2560.120.1288845124
Cefoxitin128224881324
Ceftazidime5120.120.120.12640.120.06>5120.06
Ceftazidime + CLA2560.120.120.1220.120.0620.06
Cefotaxime640.060.060.2520.250.061280.06
Cefepime320.060.060.250.250.060.06320.06
Cefpirome1280.120.060.50.50.250.12320.06
Moxalactam640.060.064420.0610.06
Aztreonam5120.060.060.06640.060.06>5120.12
Imipenem6420.062220.060.250.06
Meropenem640.250.060.250.250.250.060.060.06
  • a CLA, clavulanic acid at a fixed concentration of 2 μg/ml; TZB, tazobactam at a fixed concentration of 4 μg/ml.