TABLE 1.

Relationship between posaconazole dosing interval and outcome in a disseminated candidiasis model

EndpointDose (95% CI) for interval of:P valuea
q6hq12hq24hq48h
ED251.23 (0.7-1.8)0.84 (0.6-1.1)0.60 (0.1-1.1)0.20 (0.2-0.6)0.04
ED501.88 (1.4-2.4)1.73 (1.2-2.1)3.20 (0.3-6.1)1.90 (0.2-3.6)0.59*
ED752.86 (2.3-3.4)3.58 (3.3-3.8)14.0 (1.4-26.0)26 (1.7-49)0.07
  • a *, only significant difference in pairwise multiple comparison (Tukey test) was for dosing every 6 h (q6h) and q48h. P values are based on ANOVA.