TABLE 1.

Substitutions in AF-CYP51A resulting in azole resistance in A. fumigatus isolates

IsolateMIC (μg/ml)Substitution in AF-CYP51A
POSITZVOR
ND158a0.030.120.25None (parental strain of MS6, R4-1, and R7-1)
MS6a0.5>160.12Gly54Arg
R4-1a1>160.25Gly54Glu
R7-1a4>160.25Gly54Trp
F55064b0.250.250.25None (parental strain of F10 and F33)
F10b0.25216Gly138Arg
F33b0.250.58Gly448Ser
  • a MICs and data on mutations from Mann et al. (13).

  • b MICs from a personal communication from E. Manavathu; data on mutations as published (Manavathu et. al., 41st ICAAC).