TABLE 1.

Dalbavancin pharmacokinetic parameters following administration of a single 30-min intravenous infusion to healthy male and female subjectsa

Doseb (mg)TmaxCmax (mg/liter)AUC (mg · h/liter)CL (liters/h)Vss (liters)t1/2 (h)
1400.5 (0.5-1.0)40.1 (37.9-41.1)3,234 (3,174-3,344)0.0433 (0.0419-0.0441)10.9 (10.7-11.1)188 (186-193)
2200.5 (0.5-0.5)71.4 (48.4-76.1)5,004 (4,370-5,490)0.044 (0.0401-0.0503)11.0 (10.1-12.7)186 (172-207)
3500.5 (0.5-0.5)96.3 (89.1-103)8,104 (6,904-9,276)0.0432 (0.0377-0.0507)11.0 (8.2-12.8)188 (162-192)
5000.5 (0.5-0.5)133 (131-195)11,393 (11,200-14,758)0.0439 (0.0339-0.0446)9.01 (7.19-9.54)162 (154-163)
6301.0 (0.5-1.0)170 (143-256)12,616 (12,257-19,400)0.0499 (0.0325-0.0514)11.3 (6.96-13.2)168 (158-190)
8400.5 (0.5-0.5)239 (235-256)21,949 (21,253-23,474)0.0383 (0.0358-0.0395)7.85 (7.15-8.24)149 (148-158)
1,1200.5 (0.5-0.5)312 (292-371)27,103 (22,967-27,299)0.0413 (0.041-0.0488)7.93 (7.84-9.70)149 (145-153)
  • a The values shown are medians (ranges are in parentheses).

  • b There were three subjects in each group.