TABLE 2.

Dalbavancin pharmacokinetic parameters following administration of multiple daily 30-min intravenous infusions to healthy male and female subjectsa

Loading dose/ maintenance dose (mg)bCmax (mg/liter)Cmin (mg/liter)AUC0-24 (mg · h/liter), day 7CL (liters/h), day 7t1/2 (h), day 7
Day 1Day 7Day 1Day 7
300/3057.8 (49.0-65.2)29.5 (24.5-34.9)14.9 (10.1-18.1)22.1 (19.6-26.5)607 (517-667)0.0494 (0.045-0.0581)189 (179-207)
400/4077.4 (65.9-89.4)38.8 (37.7-51.0)21.4 (21.1-22.2)32.3 (27.3-33.2)849 (729-896)0.0471 (0.0446-0.0549)185 (166-200)
600/60111 (110-124)63.5 (60.6-66.9)29.9 (27.0-33.8)46.0 (45.3-50.1)1,248 (1,134-1,282)0.0481 (0.0468-0.0529)204 (177-213)
800/80c127 (102-164)NAd (66.2-69.2)33.3 (31.4-44.8)NA (53.5, 54.5)NA (1,345, 1,397)NA (0.0573, 0.0595)NA (189, 208)
1,000/100180 (155-205)92.6 (84.1-120)54.4 (51.3-66.0)71.0 (70.3-91.9)1,871 (1,770-2,349)0.0535 (0.0426-0.0565)188 (177-201)
  • a The values shown are medians (ranges are in parentheses).

  • b There were three subjects per group, unless noted otherwise.

  • c There were two subjects on day 7.

  • d NA, not applicable.