TABLE 1.

MICs of each antibiotic alone and time-kill results for the eight clinical A. baumannii isolates

A. baumannii isolateMIC (μg/ml)Time (h) and antibacterial effecta
IPMPBRIFIPM+PB+RIFIPM+PBPB+RIF
A32122, bactericidal4, bactericidal8, regrowth
B32124, bactericidal2, bactericidal2, bactericidal
C>32282, bactericidal8, bactericidal8, bactericidal
D>322124, bactericidal24, bactericidal8, bactericidal
E>32158, bactericidal2, regrowth24, bactericidal
F>32158, bactericidal8, bactericidal24, bactericidal
G>32818, bactericidal8, bactericidal24, bactericidal
H>321.5>3224, bactericidal8, bactericidal24, bactericidal
  • a Time-kill results are for experiments using double and triple combinations of imipenem (IPM), polymyxin B (PB), and rifampin (RIF) at 8, 0.25, and 0.5 μg/ml, respectively.