TABLE 3.

Pharmacokinetic parameters of i.v. halofantrine in different formulations

FormulationaHalofantrineDesbutylhalofantrine
AUC0.5-70 (μg · h/ml)CL (ml/h)MRT0.5-70 (h)AUC0.5-70 (μg · h/ml)MRT0.5-70 (h)
Solution1.9113.0924.411.734.4
PLA-POLOX NC12.002.0816.815.033.1
PLA-PEG NC11.802.1122.415.541.3
  • a The halofantrine concentration in NC was 0.125 mg/ml, and that in isotonic solution was 0.25 mg/ml. The total dose was 1 mg/kg.