TABLE 1.

Fungal burdens in kidneys of mice infected with C. albicans

IsolateCaspofungin MIC (μg/ml)Inoculum size (CFU/mouse [105])Median (range) log10 no. of CFU/pair of kidneys
RPMI mediumAM3ControlCaspofungin at:Fluconazole at 5 mg/kg BID
0.0625 mg/kg0.125 mg/kg0.25 mg/kg0.5 mg/kg1 mg/kg
10.25<0.1252.95.8 (5.5-7.4)5.1 (2.6-5.8)a3.9 (0-5.1)a3.8 (2.4-6.2)a2.6 (1.6-2.9)a2.9 (2.4-3.6)a5.9 (5.5-6.5)
20.25<0.12565.6 (2.4-6.4)5.6 (2.4-6.4)2.4 (1.9-3.6)a2.1 (2.0-2.9)a1.9 (1.4-3.4)a1.7 (1.7-5.2)a6.0 (5.7-7.3)
3>640.53-5.5b5.4 (3.6-6.3)5.4 (3.6-6.3)5.3 (3.0-6.3)5.2 (4.3-6.2)4.9 (3.8-5.6)4.4 (3.6-5.5)a5.5 (2.6-6.3)
  • a P ≤ 0.05 (significant reduction) compared with controls.

  • b Pooled studies.