TABLE 2.

Amino acid substitutions identified in ftsI genes from BLNAR and BLPACR II H. influenzae strainsa

SubgroupStrain or no. of strainsAmino acid substitutionMIC50 (μg/ml)
Surrounding SSN motifNear KTG motif
Met-377Ser-385Leu-389Arg-517Asn-526AMPCTXCROMEM
ControlMT1960.1250.0160.0040.031
BLNAR
    I9IleThrHis10.250.0630.125
    II2IleThrPheHis810.250.125
    III7ThrLys20.250.0630.25
    IV1IleThrLys10.1250.0310.25
    V1ThrPheLys20.1250.0630.125
    VI35IleThrPheLys40.50.1250.25
BLPACR II
    VII1ThrHis3210.250.125
    VIII6IleThrPheLys640.50.1250.25
  • a A total of 55 BLNAR strains and 7 BLPACR II strains were tested.