TABLE 1.

Antibiotic susceptibilities of P. aeruginosa strainsa

Strain(plasmid)MIC (μg/ml)
AMKGENTOBERYTETCIPFEPCAZ
PAO1420.5256320.1221
PAO1(pAZ17)0.50.250.1264160.1210.5
11B mexX::Tn50110.250.126480.0611
MutGr1841512320.541
615S*210.2525632120.5
615R*168125632241
615R(pAZ17)*0.50.250.123280.0320.5
2112S*164251232264>128
2112R*64324>1,024644>64>128
2114S*220.5256160.0614
2114R*32168256321164
2114R(pAZ17)*0.50.250.121680.0644
2116R*1684>1,024320.25816
2116R(pAZ17)*0.50.250.25512160.12416
2117R*32841,02432148
2119R*840.551232181
2119R(pAZ17)*0.50.250.1225680.581
1724R168225616142
1724R(pAZ17)0.50.250.1212880.522
1764R841512640.542
1764R(pAZ17)210.5256320.2522
1800R1642512320.25164
1800R(pAZ17)420.5256160.1282
1803R882512320.25162
1803R(pAZ17)210.5256160.1282
  • a Drug susceptibilities of isolates transformed with pAZ17 (cloned mexZ, Ticr) were determined in the presence of 250 μg of TIC/ml for plasmid maintenance. Preliminary experiments with strains PAO1, 615S, 615R, 1724R, 1764R, 1800R, and 1803R transformed with parental vector pAK1900 (Ticr) showed no influence of TIC on the MIC values compared to nontransformed strains. Similar MIC values were obtained for strain 615S harboring pAZ17. Values in boldface or in italics indicate that the bacteria were at least fourfold more or less resistant than their susceptible or resistant counterparts, respectively. CF isolates are indicated by an asterisk.