TABLE 1.

Culture results of antifungal lock studiesa

AnimalTreatmentBlood culturesQuantitative catheter cultures (log10 CFU/cath segment ± SD)
Postinfection (day 3) cathPosttreatment (day 10) cathPosttreatment (day 10) cardiac punctureProximalDistal
29709ControlPosPosPos0.894 ± 1.1890.426 ± 0.00
29711ControlClotPosNeg2.329 ± 0.1192.872 ± 0.057
41365ControlPosClotNeg2.779 ± 0.1112.891 ± 0.033
41367ControlPosClotNeg3.794 ± 0.1543.312 ± 0.036
29797ControlClotPosNeg1.387 ± 0.2341.466 ± 0.080
29049ControlPosClotPos1.076 ± 0.3570.125 ± 0.00
29044ControlClotClotNeg1.418 ± 0.1661.000 ± 0.00
29710L-AmBPosNegNeg00
29713L-AmBPosPosNeg00
29708L-AmBPosClotNeg00
41369L-AmBClotNegNeg00
41371L-AmBPosPosNeg00
29043L-AmBPosNegNeg00
29045L-AmBClotNegNeg00
29042FlucPosClotNeg1.529 ± 0.2281.316 ± 0.133
29041FlucPosNegNeg00
29046FlucPosNegNeg01.023 ± 0.707
29050FlucClotPosNeg00.813 ± 0.410
41375FlucPosNegNeg00
41374FlucClotNegNeg2.463 ± 0.0330
41364FlucPosNegNeg0.753 ± 0.000
  • a L-AmB, liposomal amphotericin B; Fluc, fluconazole; Pos, positive; neg, negative.