TABLE 4.

Mutation rates of C. glabrata parent isolates in the presence of azole antifungals

Azole antifungal (μg/ml)Mutation rate
Parent isolate 90.1085Parent isolate 94.5579
Tioconazole (20)NDaND
Miconazole (1)7 × 10−65 × 10−5
Econazole (1)1 × 10−52 × 10−4
Ketoconazole (1)1.4 × 10−42 × 10−3
Fluconazole (100)4 × 10−41 × 10−3
  • a ND, azole-resistant petite mutants were not detected (mutation rate, <10−6).