TABLE 2.

Susceptibilities of P. aeruginosa strains to antimicrobial agents

StrainGenotypeAminoglycoside- modifying enzymeMICa (μg/ml)
nalagrTicCazFepAtmAmkTobAprForCip
PAO11622440.516160.12
Mut-Gr1 agrZ 1624481 64 64 0.5
PT629 nalB 64 44 16 40.516160.25
ATM4 nalB agrZ 64 4 16 16 81NDND 1
WL22 nalB agrZ More than 2b 128 8 16 32 128 128 64 128 64
WL24 nalD agrW ANT(2′′)-I 128 8 16 32 16 64 64 128 64
1113 nalD agrZ 64 4 8 16 8132 128 0.5
1217 nalD agrZ More than 2 64 4 16 16 64 32 128 128 64
1237 nalB agrZ AAC(6′)-II 64 4 8 16 16 128 64 128 16
1250 nalC agrZ 64 4 8 16 811632 0.5
1562 nalD agrZ More than 2 64 4 16 16 128 64 128 128 32
1727 nalB nalC agrW 128 8 16 32 32 2 64 128 2
1738 nalC agrW 64 2 8 16 8132 128 0.5
2085 nalB agrZ AAC(3)-VI322 8 16 16 4 64 128 8
2151 nalB agrZ 322 8 16 81 64 128 32
2172 nalC agrZ 64 4 8 16 81 64 128 1
  • a Tic, ticarcillin; Caz, ceftazidime; Fep, cefepime; Atm, aztreonam; Amk, amikacin; Tob, tobramycin; Apr, apramycin; For, fortimicin; Cip, ciprofloxacin. Values in boldface are at least fourfold higher than that for PAO1. ND, not determined.

  • b Complex susceptibility profile suggesting the production of two or more different modifying enzymes.