TABLE 3.

MICs of polyenes and azoles for C. glabrata parent isolates and their derived petite mutantsa

Antifungal agentMIC (μgml)
Isolate 90.1085Isolate 94.5579
ParentResistant mutantETB-induced mutantParentResistant mutantETB-induced mutant
Amphotericin B0.0320.012*0.016*0.0470.012*0.023*
Tioconazole<0.125<0.125†<0.125†<0.1250.125†<0.125†
Miconazole<0.12522<0.12521
Econazole<0.12511<0.12520.5
Ketoconazole0.38680.1251612
Fluconazole32>256>25664>256>256
  • a Results are representative of two independent experiments performed in triplicate. Data were obtained by the Etest procedure for amphotericin B, ketoconazole, and fluconazole. For tioconazole, miconazole, and econazole, Etest strips were not available, and for these drugs, sensitivity was tested by a microbroth dilution method. Data were analyzed with the Kruskall-Wallis test. For all values, P < 0.001 except *, P < 0.02, and †, no differences observed.