TABLE 2.

MIC and RT-PCR data for SPRI azole-susceptible C. albicans isolates

IsolateMICa (μg/mL)ΔCTSubstitution(s) in Erg11p
POSITZFLZVORACT1PMA1ERG11MDR1CDR1CDR2
C340.0160.060.25<0.0048.17.110.311.111.313.5None
C400.0160.060.25<0.0047.26.210.611.99.614.1D116E, K128Tb
C43<0.030.060.250.037.46.310.315.110.214.4NDc
C600.0160.06<0.12<0.0047.66.38.610.911.815.9None
C720.030.060.06<0.0087.96.78.712.010.412.5D116E
C840.0080.06<0.12<0.0047.36.49.314.410.213.8D116E
C1280.0080.03<0.12<0.0047.56.111.114.410.514.6D116E, K128T,b D496
C1320.0160.060.25<0.0047.55.811.313.210.014.5D116E, K128Tb
C2940.0080.0160.25<0.0088.98.310.912.812.316.0None
C392<0.0040.030.5<0.0087.96.711.114.011.214.6None
C393<0.0040.0160.25<0.0087.86.711.313.010.714.7ND
C394<0.0040.0160.25<0.0087.96.310.916.610.613.9ND
C395<0.0040.0160.25<0.0087.96.811.512.410.715.6V437I
C548<0.004<0.008<0.125<0.0087.66.310.014.212.314.4V437I
Avg ΔCT7.86.610.413.610.814.5
SD0.40.60.920.80.9
3-SD range6.6-9.04.8-8.47.7-13.17.6-19.68.4-13.211.8-17.2
  • a POS, posaconazole; ITZ, itraconazole; FLZ, fluconazole; VOR, voriconazole.

  • b Mutation in only one copy of ERG11.

  • c ND, not done.