TABLE 2.

Maximum and minimum observed plasma voriconazole concentrations after multiple dosing

Day (dose [mg/kg])ParameterValuea
age group (yr)All subjects
2-<66-<12
4 (3)Cmin166.9 (58.6, 475.5) (n = 12)507.4 (251.6, 1,023) (n = 14)303.7 (165.0, 559.1) (n = 26)
Cmax1,642 (610.3, 4,415) (n = 10)3,843 (2,438, 6,059) (n = 12)2,611 (1,582, 4,309) (n = 22)
8 (4)Cmin263.3 (94.0, 737.7) (n = 11)696.7 (303.7, 1,598) (n = 12)437.5 (231.4, 827.1) (n = 23)
Cmax2,192 (1,257, 3,821) (n = 10)2,560 (1,381, 4,746) (n = 10)2,369 (1,626, 3,450) (n = 20)
  • a Values are geometric means (nanograms per milliliter) with 95% confidence intervals (CI) in parentheses.