TABLE 1.

In vitro activities of telavancin (TD-6424) against 271 recent clinical isolates of gram-positive anaerobes and corynebacteria

AntimicrobialMIC (μg/ml)a
Range50%90%
Actinomyces israelii (n = 13)
    Telavancin0.125-0.250.250.25
    Daptomycin0.5->3224
    Vancomycin0.5-10.51
    Linezolid0.25-160.516
    Quinupristin-dalfopristin0.125-0.50.250.25
    Imipenem≤0.03-0.25≤0.030.125
    Piperacillin-tazobactam≤0.03-4≤0.034
    Ampicillin≤0.03-0.5≤0.030.5
Actinomyces meyeri-A. turicensis groupb (n= 12)
    Telavancin0.125-0.250.1250.25
    Daptomycin0.5-1628
    Vancomycin0.25-10.50.5
    Linezolid0.125-10.50.5
    Quinupristin-dalfopristin0.06-0.50.1250.125
    Imipenem≤0.03-0.1250.1250.125
    Piperacillin-tazobactam≤0.03-20.51
    Ampicillin0.125-0.50.250.5
Actinomyces odontolyticus (n = 10)
    Telavancin0.125-0.250.250.25
    Daptomycin16->321632
    Vancomycin0.5-111
    Linezolid0.5-10.50.5
    Quinupristin-dalfopristin0.125-0.50.250.25
    Imipenem0.06-0.250.1250.125
    Piperacillin-tazobactam0.25-414
    Ampicillin0.06-0.50.1250.5
Actinomyces viscosus (n = 10)
    Telavancin0.125-0.250.1250.25
    Daptomycin0.5-848
    Vancomycin0.5-0.50.50.5
    Linezolid0.5-0.50.50.5
    Quinupristin-dalfopristin0.06-0.50.250.25
    Imipenem≤0.03-≤0.03≤0.03≤0.03
    Piperacillin-tazobactam≤0.03-0.50.1250.5
    Ampicillin≤0.03-0.060.060.06
Clostridium clostridioforme (n = 15)
    Telavancin0.25-818
    Daptomycin0.25-814
    Vancomycin0.25->320.51
    Linezolid2-424
    Quinupristin-dalfopristin0.125-80.54
    Imipenem0.5-212
    Piperacillin-tazobactam0.25-6448
    Ampicillin0.5->3211
Clostridium difficile (n = 14)
    Telavancin0.125-0.50.250.25
    Daptomycin0.5-20.52
    Vancomycin0.25-20.51
    Linezolid2-828
    Quinupristin-dalfopristin0.25-20.251
    Imipenem2-3248
    Piperacillin-tazobactam4-16816
    Ampicillin0.5-212
Clostridium innocuum (n = 15)
    Telavancin2-444
    Daptomycin2-848
    Vancomycin8-161616
    Linezolid2-422
    Quinupristin-dalfopristin0.125-10.250.25
    Imipenem1-222
    Piperacillin-tazobactam0.5-412
    Ampicillin0.125-0.250.1250.25
Clostridium perfringens (n = 12)
    Telavancin0.06-0.1250.060.125
    Daptomycin0.25-111
    Vancomycin0.5-0.50.50.5
    Linezolid2-222
    Quinupristin-dalfopristin0.125-0.50.250.5
    Imipenem≤0.03-0.250.060.125
    Piperacillin-tazobactam≤.03-20.060.5
    Ampicillin≤0.03-0.06≤0.030.06
Clostridium ramosum (n = 16)
    Telavancin0.25-80.51
    Daptomycin8->323232
    Vancomycin1-844
    Linezolid4-888
    Quinupristin-dalfopristin0.125-20.252
    Imipenem0.125-20.250.5
    Piperacillin-tazobactam≤0.03-10.060.5
    Ampicillin≤0.03-10.060.25
Eubacterium lentum (n = 10)
    Telavancin0.125-0.250.250.25
    Daptomycin1-321632
    Vancomycin0.5-111
    Linezolid0.5-222
    Quinupristin-dalfopristin0.125-0.50.250.5
    Imipenem≤0.03-0.250.250.25
    Piperacillin-tazobactam≤0.03-321616
    Ampicillin≤0.03-0.50.250.5
Eubacterium limosum (n = 10)
    Telavancin0.06-0.250.1250.25
    Daptomycin0.06-0.50.250.25
    Vancomycin0.25-222
    Linezolid1-424
    Quinupristin-dalfopristin0.125-20.251
    Imipenem≤0.03-≤0.03≤0.03≤0.03
    Piperacillin-tazobactam≤0.03-2≤0.030.25
    Ampicillin≤0.03-0.125≤0.030.06
Eubacterium groupc (n = 13)
    Telavancin0.03-10.250.25
    Daptomycin0.06-80.50.5
    Vancomycin0.25-412
    Linezolid0.5-222
    Quinupristin-dalfopristin≤0.03-10.51
    Imipenem≤0.03-0.125≤0.03≤0.03
    Piperacillin-tazobactam≤0.03-0.5≤0.030.5
    Ampicillin≤0.03-0.125≤0.030.06
Lactobacillus plantarum (n = 10)
    Telavancin0.125-0.250.250.25
    Daptomycin8->3232>32
    Vancomycin0.5-444
    Linezolid4-888
    Quinupristin-dalfopristin0.5-20.52
    Imipenem0.125-0.50.1250.25
    Piperacillin-tazobactam≤0.03-10.060.5
    Ampicillin≤0.03-0.5≤0.030.25
Lactobacillus casei (n = 6)
    Telavancin32->6432
    Daptomycin1-42
    Vancomycin>32->32>32
    Linezolid44
    Quinupristin-dalfopristin0.5-11
    Imipenem1-162
    Piperacillin-tazobactam1-84
    Ampicillin0.5-41
Lactobacillus sp.d (n = 16)
    Telavancin≤0.015-20.251.25
    Daptomycin0.25->324>32
    Vancomycin0.25-814
    Linezolid1-848
    Quinupristin-dalfopristin0.125-40.251
    Imipenem≤0.03-10.060.25
    Piperacillin-tazobactam≤0.03-10.251
    Ampicillin≤0.03-10.1250.5
Propionibacterium acnes (n = 12)
    Telavancin0.06-0.1250.1250.125
    Daptomycin0.125-10.51
    Vancomycin0.25-0.50.50.5
    Linezolid0.25-0.50.50.5
    Quinupristin-dalfopristin≤0.03-0.50.1250.125
    Imipenem≤0.03-≤.03≤0.03≤0.03
    Piperacillin-tazobactam≤0.03-0.50.1250.5
    Ampicillin≤0.03-0.1250.060.06
Propionibacterium avidum (n = 12)
    Telavancin0.125-0.250.1250.125
    Daptomycin1-222
    Vancomycin0.5-0.50.50.5
    Linezolid0.5-10.50.5
    Quinupristin-dalfopristin0.125-0.1250.1250.125
    Imipenem≤0.03-≤0.03≤0.03≤0.03
    Piperacillin-tazobactam≤0.03-10.51
    Ampicillin≤0.03-0.1250.1250.125
Propionibacterium granulosum (n = 10)
    Telavancin0.06-0.1250.060.125
    Daptomycin0.125-10.51
    Vancomycin0.5-10.51
    Linezolid0.25-0.50.250.25
    Quinupristin-dalfopristin0.06-0.1250.1250.125
    Imipenem≤0.03-0.06≤0.03≤0.03
    Piperacillin-tazobactam≤0.03-1≤0.03≤0.03
    Ampicillin≤0.03-0.50.060.06
Peptostreptococcus anaerobius (n = 10)
    Telavancin0.06-0.250.060.25
    Daptomycin0.25-40.250.5
    Vancomycin0.25-0.50.250.5
    Linezolid0.5-80.58
    Quinupristin-dalfopristin0.06-0.50.1250.25
    Imipenem≤0.03-0.06≤0.030.06
    Piperacillin-tazobactam≤0.03-10.250.25
    Ampicillin≤0.03-0.1250.060.125
Peptoniphilus asaccharolyticuse (n = 10)
    Telavancin00.03-0.0600.030.06
    Daptomycin≤0.03-0.25≤0.03≤0.03
    Vancomycin0.06-0.50.1250.125
    Linezolid0.5-10.51
    Quinupristin-dalfopristin0.25-0.50.50.5
    Imipenem≤0.03-≤0.03≤0.03≤0.03
    Piperacillin-tazobactam≤0.03-0.06≤0.03≤0.03
    Ampicillin≤0.03-0.125≤0.030.06
Finegoldia magnae (n = 11)
    Telavancin00.03-0.250.060.06
    Daptomycin0.25-40.51
    Vancomycin0.25-10.250.5
    Linezolid0.5-212
    Quinupristin-dalfopristin0.25-0.50.250.5
    Imipenem≤0.03-0.125≤0.030.125
    Piperacillin-tazobactam≤0.03-0.50.1250.5
    Ampicillin≤0.03-0.250.1250.25
Micromonas microse (n = 10)
    Telavancin0.06-0.1250.060.125
    Daptomycin0.25-10.50.5
    Vancomycin0.25-0.50.50.5
    Linezolid0.5-10.51
    Quinupristin-dalfopristin0.5-10.51
    Imipenem≤0.03-0.125≤0.03≤0.03
    Piperacillin-tazobactam≤0.03-0.25≤0.03≤0.03
    Ampicillin≤0.03-≤0.03≤0.03≤0.03
Anaerococcus prevotiie (n = 11)
    Telavancin≤.015-0.50.030.06
    Daptomycin≤0.03-160.060.125
    Vancomycin0.125-10.50.5
    Linezolid≤0.03-20.51
    Quinupristin-dalfopristin≤0.03-10.250.5
    Imipenem≤0.03-0.06≤0.03≤0.03
    Piperacillin-tazobactam≤0.03-0.125≤0.030.06
    Ampicillin≤0.03-0.125≤0.030.06
Corynebacterium amycolatum (n = 10)
    Telavancin0.03-0.060.030.06
    Daptomycin≤0.03-0.1250.060.06
    Vancomycin0.25-0.50.50.5
    Linezolid0.25-0.50.50.5
    Quinupristin-dalfopristin0.125-0.250.250.25
    Imipenem≤0.03->320.125>32
    Piperacillin-tazobactam≤0.03->1284>128
    Ampicillin0.06->322>32
Corynebacterium jeikeium (n = 11)
    Telavancin0.03-0.060.060.06
    Daptomycin0.125-0.50.250.5
    Vancomycin0.5-0.50.50.5
    Linezolid0.5-0.50.50.5
    Quinupristin-dalfopristin0.25-10.250.5
    Imipenem1->32>32>32
    Piperacillin-tazobactam64->128>128>128
    Ampicillin>32->32>32>32
Corynebacterium groupf (n = 10)
    Telavancin≤0.015-0.03≤0.0150.03
    Daptomycin≤0.03-0.1250.060.06
    Vancomycin0.125-0.50.250.5
    Linezolid0.125-0.50.250.5
    Quinupristin-dalfopristin0.125-20.50.5
    Imipenem≤0.03->320.0432
    Piperacillin-tazobactam≤0.03->128432
    Ampicillin≤0.03->320.532
  • a 50% and 90%, MIC50 and MIC90, respectively.

  • b A. meyeri (n = 5) and A. turicensis (n = 7).

  • c E. contortum (n = 2), E. moniliforme (n = 1), E. tenue (n = 2), Pseudoramibacter alactolyticus (n = 7), and Eubacterium sp., no good fit (n = 1).

  • d Includes L. acidophilus (n = 2), L. catenaforme (n = 8), L. gasseri (n = 1). L. jensenii (n = 2), L. leichmannii (n = 1), L. rhamnosus (n = 1), and L. uli (n = 1).

  • e Formerly Peptostreptococcus.

  • f C. pseudodiphtheriticum (n = 3), C. striatum (n = 6), and Brevibacterium sp. (n = 1).