TABLE 3.

MIC and RT-PCR data for C. albicans isolates from candidiasis patients

Patient no.Isolate no.MICa (μg/ml)ΔCTbSubstitution(s) in Erg11p
POSITZFLZVORACT1PMA1ERG11MDR1CDR1CDR2
1C4820.250.5160.57.97.510.413.79.2 9.4 A107T
C4860.251160.258.08.19.812.311.2 10.1 A107T
2C4910.120.2520.037.47.28.912.910.1 10.0 D116E
C5040.250.25160.257.36.27.915.5 8.2 7.7 F449S
3C4980.0080.0610.0087.45.49.612.6 8.2 10.8 F145L, E266D, V488I
C5020.0080.0610.0087.25.9 7.4 11.710.6 10.8 F145L, E266D, V488I
C5130.250.25160.126.76.4 7.5 10.6 7.6 5.8 F145L, E266D, V488I
4C5270.120.525647.56.69.112.68.9 8.6 Y132H, G450E
C5280.120.525647.35.99.011.7 7.7 7.7 Y132H, G450E
C5300.120.252560.57.06.38.512.08.8 9.9 G450E, G464S
C5340.120.525647.36.48.111.0 8.3 8.8 Y132H, G450E
C5460.120.2512828.17.59.611.99.4 9.4 Y132H, G450E
C5360.250.525648.27.79.811.79.2 9.4 Y132H, G450E
C5720.250.25>25688.07.49.512.19.5 9.2 Y132H, G450E
5C4810.250.5320.57.97.29.915.79.4 9.0 F128T, F145L
C4830.250.580.128.27.311.014.810.0 9.5 F145L
6C5350.5225687.77.19.89.09.6 10.9 Y132H, G448V
C5390.25212887.26.811.08.3 6.6 7.1 Y132H, G448V
7C5160.120.25320.57.37.19.814.09.7 9.7 K128T, Y132F, F145L
8C4700.50.5320.257.37.09.013.58.7 8.5 S405F
C4780.50.5640.57.66.98.612.69.1 8.5 S405F
9C4900.51320.258.37.810.69.49.0 9.2 V452A
C4970.52640.58.47.79.112.510.0 9.3 K128T, V452A
10C5260.51320.57.87.19.613.69.2 9.2 V509M
C5330.50.53217.97.49.813.69.3 9.9 V509M
11C5940.52128167.26.59.011.3 8.2 7.5 Y132H, S405F
C60014>256167.77.18.512.39.4 8.2 Y132H, S405F
12C5770.060.061280.5 6.5 5.09.0 5.3 8.1 12.9G464S
C5830.250.2525616.85.59.4 5.7 6.9 10.7 G464S
C5870.50.525647.77.39.28.210.2 9.6 G464S
13C4800.030.1212888.37.49.39.212.215.1K128T, G464S, R467I
14C4380.50.512826.66.07.913.3 7.1 7.5 Y257H, G464S
C43914>256167.16.2 7.6 13.5 7.7 7.5 Y257H, G464S, G307S
C44048>256>167.36.48.013.5 7.9 7.7 Y257H, G464S, G307S, A61V
15C4440.50.52560.57.05.8 7.4 13.2 7.8 7.8 K143R
16C4890.250.2512817.26.18.812.810.1 9.5 Y132H, Y257H, E266D
17C47710.25256167.66.19.3 7.3 10.515.3K128T, G464S, R467I
18C50712648 6.1 7.28.610.5 8.3 8.4 Y132H, H283R, G464S
  • a See Table 2, footnote a.

  • b Values that fall outside the 3-SD range measured in the azole-susceptible isolates (see text for details) are shown in boldface italic.