TABLE 4.

Subpopulation of candidiasis patients colonized by C. albicans isolates exhibiting cross-resistance to fluconazole and voriconazolea

Patient no.Isolate no.MIC (μg/ml)ΔCTSubstitution(s) in Erg11p
POSITZFLZVORACT1PMA1ERG11MDR1CDR1CDR2
4C5270.120.525647.56.69.112.68.9 8.6 Y132H, G450E
C5280.120.525647.35.99.011.7 7.7 7.7 Y132H, F155L, G450E
C5340.120.525647.36.48.111.0 8.3 8.8 Y132H, G450E
C5460.120.2512828.17.59.611.99.4 9.4 Y132H, G450E
C5360.250.525648.27.79.811.79.2 9.4 Y132H, G450E
C5720.250.25>25688.07.49.512.19.5 9.2 Y132H, G450E
6C5350.5225687.77.19.89.09.6 10.9 Y132H, G448V
C5390.25212887.26.811.0 8.3 6.6 7.1 Y132H, G448V
11C5940.52128167.26.59.011.3 8.2 7.5 Y132H, S405F
C60014>256167.77.18.512.39.4 8.2 Y132H, S405F
12C5870.50.525647.77.39.2 8.2 10.2 9.6 G464S
13C4800.030.1212888.37.49.39.212.215.1K128T, G464S, R467I
14C4380.50.512826.66.07.913.3 7.1 7.5 Y257H, G464S
C43914>256167.16.2 7.6 13.5 7.7 7.5 Y257H, G464S, G307S
C44048>256>167.36.48.013.5 7.9 7.7 Y257H, G464S, G307S, A61V
17C47710.25256167.66.19.3 7.3 10.515.3K128T, G464S, R467I
18C507126486.17.28.610.5 8.3 8.4 Y132H, H283R, G464S
  • a See Table 2, footnote a, and Table 3, footnote b.