TABLE 1.

Demographic characteristics of patients enrolled in study

ParameterValue
Single-dose study (n = 11)Multiple-dose study (n = 24)aTotal (n = 35)
Mean age (yr)5.96.46.2
Age distribution (yr)2-<62-<6
6-<126-<12
Mean wt (kg) (range)21.5 (15-36)24.3 (12-54)23.4 (12-54)
No. of patients with     CYP2C19 genotype
    EM41822
    PM202
    HEM5611
No. of patients with ethnic origin
    Caucasian101626
    Black101
    Asian011
    Other077
No. of patients with     underlying condition
    Leukemia51116
    Bone marrow transplant088
    Lymphoma112
    Other549
  • a Twenty-eight subjects entered the study; four were not included in the population pharmakokinetic modeling, as their CYP genotypes were not determined.