TABLE 5.

Patients with voriconazole dose reduced or discontinued due to AE or laboratory abnormalities

Change in voriconazoleUnderlying diseaseaDay of dose reduction or discontinuationReasonOutcome
DiscontinuedAML13Subdural hematomaDied 4 days later
DiscontinuedALL6Fever and viral enteritisResolved in 3 days
DiscontinuedALL3FeverResolved in 33 days
Dose reduced then discontinuedRelapsed ALL BMTDose reduced on day 8, discontinued on day 11Elevated serum creatinine (1.2 × ULN)Died 6 days later due to bacterial sepsis and meningitisb
DiscontinuedFanconi's anemia; autoimmune hepatitis7Elevated AST and ALT (10 × ULN)AST and ALT normalized in 34 days
Dose reducedALL; BMT14Abnormal renal function and elevated serum creatinineResolved in 27 days
  • a ALL, acute lymphoblastic leukemia; AML, acute myelogenous leukemia; BMT, blood and marrow transplantation.

  • b Stomatococcus mucilaginosus.