TABLE 3.

Susceptibilities to fluoroquinolones of pneumococcal isolates from 12 Asian countriesa

CountryLevofloxacinMoxifloxacinGatifloxacinCiprofloxacin
MIC (mg/liter)% I% RMIC (mg/liter)% I% RMIC (mg/liter)% I% RMIC (mg/liter)% R
90%Range90%Range90%Range90%Range
Korea20.25-20.00.00.250.06-0.50.00.00.50.12-10.00.020.25-46.5
China10.12-20.00.00.250.004-10.00.00.5<0.03-10.00.020.12->323.6
Thailand10.5-20.00.00.250.03-0.50.00.00.5<0.03-10.00.020.5-83.8
Taiwan10.5-20.01.80.250.03-0.51.80.00.50.03-11.81.820.5-87
India10.06-80.01.30.250.015-21.30.00.5<0.03-80.01.420.12-164
Sri Lanka10.5-20.00.00.250.06-0.50.00.00.50.12-10.00.020.5-49.5
Singapore10.12-42.90.00.120.015-0.250.00.00.50.06-10.00.020.5-165.9
Malaysia10.015-20.00.00.25<0.002-10.00.00.50.06-10.00.02<0.015-44.6
Vietnam10.25-10.00.00.250.06-0.250.00.00.50.06-10.00.020.12->44.8
Philippines10.5-20.00.00.250.03-0.50.00.00.50.06-10.00.020.5-49.1
Saudi Arabia1<0.004-20.00.00.25<0.002-0.250.00.00.50.015-10.00.02<0.015-42.6
Hong Kong20.015-320.08.00.50.015-46.31.810.03-80.98.340.015-3211.8
    Total1<0.004-320.11.60.25<0.002-41.30.30.50.03-80.31.620.008->326
  • a MIC breakpoints for individual fluoroquinolones are as follows: for levofloxacin, I = 4 mg/liter and R = 8 mg/liter; for moxifloxacin, I = 2 mg/liter and R = 4 mg/liter; for gatifloxacin, I = 2 mg/liter and R ≥ 4 mg/liter; and for ciprofloxacin R ≥ 4 mg/liter.