TABLE 3.

Simulated pharmacokinetic data for pediatric and adult populations

ParameterValuea
PediatricAdult
3b434
AUCτ (ng · h/ml)10,67014,22713,85538,605
Cmean (ng/ml)8891,1861,1553,217
  • a Data are reported as medians following 6 mg/kg 12 every h on day 1 and maintenance dose 3. The values are derived from population pharmacokinetic analyses of 236 healthy volunteers.

  • b Dosage (milligrams per kilogram).