TABLE 2.

Teicoplanin MICs for different S. aureus strains in broth, human serum, and ultrafiltrate and bactericidal activities of sera of the subjects after 8 and 24 hs of contact

S. aureus StrainMIC (mg/liter) in:Mean change (log of CFU/ml) between the following times in the indicated mediuma
MHBSerumUltrafiltrateSerumUltrafiltrate
8 h − time zero24 h − time zero8 h − time zero24 h − time zero
54930.521−2.1−2.34.94.7
5497142−2.3−2.84.54.4
6011242−2.8−3.34.02.8
6005284−1.8−2.34.03.3
6017444−2.5−3.23.93.3
6026484−2.1−3.04.03.7
195281616NCNC4.84.5
  • a Mean log difference in viable counts in CFU/per milliliter between the evaluation time and the time of origin (i.e., the duration of the contact) in sera of healthy volunteers (n = 48 samples). NC, not calculated on account of the heterogeneity between samples (i.e., the absence of bactericidal activity in some serum samples).