TABLE 2.

Summary of pharmacokinetic parameters and variability for antimicrobials used in the Monte Carlo simulationc

AntibioticPharmacokinetic parameter (mean ± SD)
CLT (liters/h)cVd (liters)cFraction unbound (%)a
Meropenem14.4 ± 1.818.6 ± 3.085-98
Imipenem10.5 ± 1.415.3 ± 3.380-95
Ceftazidime9.3 ± 3.314.0 ± 2.980-90
Cefepime5.3 ± 0.613.6 ± 2.480-90
Piperacillin-tazobactam10.9 ± 1.211.9 ± 1.765-75
Ciprofloxacinb31.2 ± 6.360-80
  • a Fraction unbound, presented as a range.

  • b Fraction unbound for ciprofloxacin is listed in the table but was not used in analysis.

  • c Results are expressed as means ± standard deviations.