TABLE 1.

Triclosan MICs and antibiotic susceptibility

Organism and sampling pointNo. of isolatesaTriclosan MIC (μg/ml) at percentile:Antibiotic resistance (%)
25th50th75th
A. baumannii
    Baseline101.001.502.001.0
    1 yr260.130.251.2518.4
A. lwoffiib
    Baseline220.502.002.009.1
    1 yr330.061.002.0015.2
E. agglomerans
    Baseline210.130.130.250
    1 yr180.060.130.2511.1
E. cloacaec
    Baseline250.130.501.0036
    1 yr130.130.130.250
K. pneumoniaeb
    Baseline400.5016.50>32.0015
    1 yr290.250.501.006.9
P. fluorescens-P. putida
    Baseline150.500.50>32.0045.3
    1 yr140.228.00>32.0042.9
S. aureusb
    Baseline302.002.002.006.7
    1 yr130.030.030.277.7
S. capitis
    Baseline50.060.060.0640
    1 yr360.060.062.0011.1
S. epidermidis
    Baseline200.030.092.0030
    1 yr530.030.060.2534
S. warneri
    Baseline280.060.060.2539.3
    1 yr1270.060.060.2533.1
  • a There were totals of 171 GNB strains at baseline and 133 GNB strains at the end of the year and totals of 53 CNS strains at baseline and 216 strains at the end of the year.

  • b There was a significantly higher proportion of A. lwoffii for which the triclosan MICs were greater than the median at the end of the year compared to the baseline (P = 0.001) as determined by Fisher exact test. There were significantly higher proportions of K. pneumoniae and S. aureus for which the triclosan MICs were greater than the median at baseline compared to the end of the year (P = 0.013 and P < 0.001, respectively) as determined by the chi-square or Fisher exact tests. There were no significant differences when we compared the proportion of triclosan MIC values greater than the median at baseline versus that at the end of the year for any of the other organisms (all P > 0.05).

  • c There was a significantly higher proportion of antibiotic-resistant E. cloacae at baseline compared to at the end of the year (P = 0.016) as determined by using the Fisher exact test. There were no significant differences in antibiotic resistance for any of the other species when we compared baseline levels to those at the end of the year (all P > 0.05).