TABLE 3.

Point dose estimates needed against infection caused by MRSA 33591 in MNT and MSI modelsa

DrugDoseb (mg/kg) needed in modelED50 ratio (MNT/MSI)ED1-log kill ratio (MNT/MSI)
MNTMSI
EDstasisED50ED1-log killEDstasisED50ED1-log killED2-log kill
Telavancin6.32.527.50.80.92.1102.713
Vancomycin34.610.6199.52.82.83.9103.851
Linezolid109.679.4>5002.32.32.6>50034.5>192
  • a Refer to Materials and Methods for definition of pharmacodynamic endpoints. MNT, mouse neutropenic thigh; MSI, mouse subcutaneous infection.

  • b Dose administered i.v.