TABLE 1.

Susceptibilities of porin-deficient K. pneumoniae strain C2 containing various plasmid-mediated β-lactamases

Enzyme groupβ-LactamasePlasmidMIC (μg/ml)
CefepimeCefotaximeCefoxitinCeftazidimeErtapenemImipenemMeropenem
None0.50.5640.5110.25
1ACC-1pSLK548128≥1,024≥2563284
ACT-1pMG2512128≥1,02464≥1286416
CMY-2pMG2504128≥1,02412832328
DHA-1pMG2474256≥1,024≥256128648
FOX-1pGL3a16≥256≥1,024≥2561286416
FOX-3p1734232≥1,024128822
FOX-5pMG252464≥1,024128821
LAT-1pHP158≥256≥1,024≥256643216
MIR-1pMG233264≥1,0243232328
MOX-1pRMOX-1432≥1,024643288
MOX-2pKOL864≥1,0241281622
2bTEM-1R10.50.5640.5210.5
TEM-2RP140.5641822
2beTEM-3pCFF043212864128821
TEM-4pUD163212864321624
TEM-5pCFF141616642561641
TEM-6pMG22616416≥2563211
TEM-7pIF10032264641622
TEM-8Plasmid from E. coli CF804321664≥2561620.5
TEM-9pMG228321664≥2563240.5
TEM-10pMG22316464≥2561620.5
TEM-11pMG24416264641624
TEM-12pMG22416264641620.5
TEM-15pMG274166464≥256822
TEM-16Plasmid from K. pneumoniae CF130416464≥256810.5
TEM-19pMG28986432641641
TEM-20pUD3064326416422
TEM-21pUD3116128642561640.5
TEM-22Plasmid from E. coli HB101 TEM-2286464≥2561620.25
TEM-24Plasmid from K. pneumoniae CF1104163264≥25680.50.5
TEM-25Plasmid from E. coli CF1609163264321640.25
TEM-26pMG22532464≥256810.25
TEM-52pMG2768326464840.5
TEM-61pMG2908416≥2561642
TEM-71pMG25910.564256840.125
TEM-88pMG27283264641620.5
2bSHV-1R10100.50.5640.520.50.5
2beSHV-2pMG25816464≥256810.25
SHV-3pUD18326464≥256421
SHV-4pUD218166425640.50.25
SHV-5pAFF2163264≥256822
SHV-6pSLH4710.5643280.51
SHV-12pMG2424432≥256422
SHV-18pMG266486464812
CTX-M-5pCLL3417a128≥256644821
CTX-M-14pMG2673232648822
2bHMS-1R9970.50.564120.51
2cPSE-1pMG2170.50.5644210.5
PSE-4pUZ8::Tn14050.50.5640.5212
CARB-3pUZ8::Tn140810.5640.5111
CARB-4pUZ8::Tn14130.50.25320.5112
SAR-1pUK6570.50.5640.5210.5
2dOXA-1RGN23840.5640.5212
OXA-2R460.50.564163221
OXA-3R550.250.2516210.52
OXA-4pMG20310.5640.5110.25
OXA-5pMG540.50.5640.5110.25
OXA-7pMG20211321112
OXA-10pUZ8::Tn14040.50.5640.5212
LCR-1pUZ8::Tn14120.50.5640.520.51
2fKPC-1pBR322-catI-blaKPC-1a12812812864≥128≥128≥128
3VIM-2pNOR2001a464128326464128
  • a Multicopy recombinant plasmid.