TABLE 6.

Genes upregulated in the benomyl and MDR experiments

Function group and nameFunctionaCap1p binding site position(s)bFold increase (−) in expt
MDRBenomyl
Other
    IPF3080Unknown−213, −7084.11.6
    IPF1617Unknown−2077.33.2
    IPF11023Unknown4.32.6
Transport (CaMDR1)Multidrug transporter activity; similar to S. cerevisiae FLR1−53244.012.6
Response to stress
    IPF18418Unknown; similar to S. cerevisiae YHR029c (induced by cell-damaging conditions)5.41.6
    IPF13316Unknown; similar to S. cerevisiae YNL010w (induced by cell-damaging conditions)4.11.7
    IPF5987Unknown; similar to S. cerevisiae YPR127w (protein with similarity to S. pombe pyridoxal reductase, aldo-keto reductase family)70.27.9
    IPF17186Unknown; similar to S. cerevisiae YDR533c (induced by cell-damaging conditions)−720102.556.8
    PYC2Pyruvate carboxylase 2; similar to S. cerevisiae YBR218c5.11.9
    GPX1Glutathione peroxidase; similar to S. cerevisiae HYR19.43.6
    GRP2Reductase; similar to S. cerevisiae YOL151w (induced by osmotic stress)−44452.535.1
    IPF7817Putative NADH-dependent flavin oxidoreductase by homology; similar to S. cerevisiae OYE3−74314.737.0
    DDR48Stress protein; similar to S. cerevisiae YMR173w (involved in the production of or recovery from mutation)5.61.7
    IFD1Benzyl alcohol dehydrogenase activity (by homology); similar to S. cerevisiae YPL088w (aldo-keto reductase family)748.332.6
    IFD4Benzyl alcohol dehydrogenase activity (by homology); similar to S. cerevisiae YPL088w (aldo-keto reductase family)129.66.7
    IFD5Benzyl alcohol dehydrogenase activity (by homology); similar to S. cerevisiae YPL088w (aldo-keto reductase family)511.216.1
    IFD7Benzyl alcohol dehydrogenase activity (by homology); similar to S. cerevisiae YPL088w (aldo-keto reductase family)158.95.4
  • a Gene functions were obtained using the CandidaDB and MycoPathPD databases available from the Pasteur Institute and from Incyte.

  • b The sequence of the Cap1p-binding site considered is TTA(C/G)TAA (15).