TABLE 2.

Association between high triclosan MICsa and antibiotic resistance: OR and aOR estimates

Organism and sampling point (n)Odds of antibiotic resistance among species for which triclosan MICs were high
OR (95%CI)PaOR (95%CI)P
All species combined
    Baseline (220)0.65 (0.33-1.27)0.20--
    End of yr (290)b0.92 (0.53-1.59)0.761.08 (0.62-1.97)0.73
GNB only
    Baseline (150)c0.71 (0.32-1.55)0.390.66 (0.29-1.51)0.33
    End of yr (93)d2.31 (0.75-7.12)0.142.69 (0.78-9.23)0.12
Staphylococci only
    Baseline (70)e0.64 (0.21-1.95)0.430.69 (0.20-2.42)0.56
    End of yr (197)c0.74 (0.38-1.45)0.380.70 (0.35-1.38)0.30
  • a “High triclosan MICs” refers to organisms that were in the upper 75th percentile MIC distribution. For each model, cofactors that were assessed included assigned soap user group (antibacterial versus plain), use of antibacterial cleaning and hygiene products in the home before study initiation, observed length of hand wash, and reported number of hand washes per day. For the models examining the species combined, we also assessed the type of species (GNB or staphyloccoci) as a cofactor. These variables were only included in the final model if there was a >10% change in the regression coefficient compared to the model examining the triclosan level alone. n, number of isolates.

  • b The aOR is controlling for the type of species (i.e., either GNB or staphylococci), the reported number of hand washes per day, and prior antibacterial cleaning and hygiene product use.

  • c The aOR is controlling for the observed number of seconds hands were washed.

  • d The aOR is controlling for the reported number of handwashes per day.

  • e The aOR is controlling for the observed number of seconds hands were washed and assigned antibacterial soap use.