TABLE 1.

Oritavancin accumulation by different cell typesa

Cell typeAccumulation ratiob (no. of determinations)
J774 mouse macrophages66.4 ± 11.8 (12)
THP-1 human monocytes84.3 ± 7.0 (9)
Rat embryo fibroblasts72.4 ± 9.4 (6)
LLC-PK1 pig kidney proximal tubular cells37.8 ± 6.4 (3)
Caco-2 human colorectal cells13.8 ± 0.4 (3)
  • a The cells were incubated for 2 h at 37°C with 25 mg of the drug per liter in a medium containing 10% FCS.

  • b Ratio of cellular concentration to extracellular concentration.