TABLE 3.

Drug susceptibility testing of Kenyan P. falciparum against a panel of antimalarial compounds

DrugIC50 (ng/ml) for isolates froma:
Entosopia (7)Magadi (7)Kericho (5)Kisumu (4)
Median (range)Median (range)Median (range)Median (range)
Quinine48 (27-79)44 (11-96)14 (10-17)56 (20-122)
Artemisinin1.0 (0.6-1.3)2 (0.6-2)1 (0.8-1)2 (1-2)
Halofantrine7 (.8-14)7 (2-10)0.2 (0.1-0.3)8 (1-20)
Doxycycline3,591 (1380-8527)5,303 (3120-7686)2,718 (1746-3670)6,244 (5781-6333)
Atovoquone2 (0.8-14)2 (0.8-3)NTb0.8 (0.3-1)
Tafenoquine848 (478-1528)913 (813-1043)NT1,046 (812-1417)
Amodiaquine10 (7-13)13 (8-14)3 (2-5)10 (4-13)
Primaquine656 (349-1255)504 (270-1276)416 (32-602)464 (289-566)
Dapsone28 (4-74)1,926 (60-3522)NT2,804 (2345-3518)
Proguanil54 (37-86)905 (361-2475)2275 (2172-2523)556 (412-715)
Chlorcycloguanil3 (2-5)8 (1-17)NT5 (2-12)
  • a Number of samples tested is given in parentheses after name of region.

  • b NT, not tested.