TABLE 2.

Susceptibility of P. falciparum isolated from Kenya to four common antimalarial drugs

Location (na)IC50 (ng/ml)b
ChloroquineMefloquineSulphadoxinePyrimethamine
Median (range)Median (range)Median (range)Median (range)
Entosopia (7)45 (33-75)13 (3-27)4,362 (1490-7412)200 (99-375)
Magadi (7)30 (11-71)7.4 (0.8-15)6,430 (5545-6966)333 (41-742)
Kericho (5)15 (2-31)0.8 (0.6-1.0)1,070 (705-1650)295 (120-473)
Kisumu (4)12 (1.0-33)8.0 (5-9)8,429 (7845-9438)203 (109-240)
  • a n, number of samples tested.

  • b The following IC50s are considered discriminative for resistance; chloroquine, >45.5 ng/ml; quinine, >275 ng/ml; mefloquine, >10 ng/ml; halofantrine, >2ng/ml; pyrimethamine, >15 ng/ml; cycloguanil, >15 ng/ml; sulfadoxine, >10,000 ng/ml; dapsone, >300 ng/ml (18, 24, 43, 47).