TABLE 2.

Clarithromycin, erythromycin, telithromycin, and chloramphenicol susceptibilities of E. aerogenes strainsa

E. aerogenes strainInhibitor concn (μg/ml)MIC (μg/ml)
ClarithromycinErythromycinTelithromycinChloramphenicol
ATCC 130480256512644
10.54161
26.3140.254
EAEP289 (AcrAB over producer)0512512641,024
10.532328
26.3480.564
EAEP294 (AcrA)01281283232
10.5882
26.3120.064
EAEP298 (TolC)032161632
10.5211
26.3110.064
EAEP294(pAcrAB)025625664nd
10.51684
26.3410.5nd
EAEP298(pTolC)025625664nd
10.516164
26.3221nd
  • a Antibiotics were tested alone or with various PAβN concentrations as previously described (4). MICs for the E. aerogenes strains with 526 μg of PAβN/ml have been previously determined (3, 12). The MICs were determined for strains in Mueller-Hinton broth as previously described (4). The MIC values shown are results of three independent experiments. nd, not determined.