TABLE 1.

MICs of ciprofloxacin, gatifloxacin, gemifloxacin, levofloxacin, and moxifloxacin for all S. pneumoniae isolates used in mutational studiesa

IsolateGenetic constitution of isolates prior to mutational analysisMIC (μg/ml)
ParCGyrAEffluxCIPGATGEMLVXMXF
2670wtwtNegative10.250.0160.50.06
2587wtwtNegative10.250.0160.50.06
2663wtwtNegative10.1250.0080.50.06
4610Ser79PhewtNegative40.50.0620.25
14744Ser79PhewtNegative40.50.0620.25
1146wtSer81PheNegative840.0682
15017wtwtPositive40.250.0620.12
16072wtwtPositive40.50.0620.12
  • a wt, wild type; CIP, ciprofloxacin; GAT, gatifloxacin; GEM, gemifloxacin; LVX, levofloxacin; and MXF, moxifloxacin.