TABLE 2.

MPCs obtained for single-step fluoroquinolone-resistant mutants of S. pneumoniae isolatesa

IsolateCiprofloxacinGatifloxacinGemifloxacinLevofloxacinMoxifloxacin
MPMICMPC (μg/ml)MPMICMPC (μg/ml)MPMICMPC (μg/ml)MPMICMPC (μg/ml)MPMICMPC (μg/ml)
Wild-type GyrA and ParC, efflux negative
    2587161620.580.134280.5
    26638881160.134280.5
    26708820.540.0642161
ParC Ser79Phe, wild-type GyrA, efflux negative
    4610166416880.51632>16>4
    1474416641681611632164
GyrA Ser81Phe, wild-type ParC, efflux negative
    11468641480.521624
Efflux positive, wild-type GyrA and ParC
    150174168240.254881
    160724164240.252440.5
  • a MPMIC are given in multiples of the MIC of each drug.