TABLE 5.

Clinical features and outcomes of bloodstream infections due to DHA-1-related AmpC β-lactamase-producing K. pneumoniae isolatesa

Isolate no.Age (yr)/sexUnderlying diseaseComorbid conditionType or site of infectionEmpirical therapyDefinitive therapyOutcome
960/MColon cancerBiliary invasionCholangitisCAZ, AMKIPMPersistent fever after 3 days; treatment changed to imipenem, with cure
1050/MHCCTACEUnknownCTX, AMKIPMPersistent fever after 4 days; treatment changed to imipenem, with cure
1275/MHCCICU, post-op. C-linePeritonitisCTX, AMKIPMPersistent fever after 4 days; treatment changed to imipenem, with cure
1843/MDM, LCICU carePeritonitisCTX, AMKCTX, AMKDeath on day 3 of treatment
1943/FBrain tumorCraniotomy, post-op.Urinary tract infectionCIPIPMPersistent fever after 3 days; treatment changed to imipenem, with cure
2165/MLCNonePeritonitisCAZCAZProgression to infected right pleural effusion; death on day 16 of treatment
2358/FCBD stonePost-ESTCholangitisCAZCAZDeath on day 3 of treatment
2854/MLeukemiaNeutropenia, C-lineUnknownZOX, AMKIPMPersistent fever after 3 days; treatment changed to imipenem, with cure
3654/FLCFoley catheter, C-linePeritonitisCTX, AMKCTX, AMKDeath on day 3 of treatment
3743/FMCTDICU, Foley catheter, C-linePneumoniaCAZ, AMKIPM, AMKPersistent fever after 7 days; treatment changed to imipenem, but with death on day 29 of treatment
4263/MPancreas cancer, DMNoneCholangitisCTX, AMKIPMPersistent fever after 3 days; treatment changed to imipenem, with cure
4350/MHCCTACELiver abscessCTXIPMPersistent fever after 5 days; treatment changed to imipenem, with drainage, cured
5717/MAplastic anemia, BMTNeutropenia, C-lineUnknownZOX, AMKIPM, CIPPersistent fever after 7 days; treatment changed to imipenem and ciprofloxacin, but with death on day 22 of treatment
  • a Abbreviations: M, male; F, female; DM, diabetes mellitus; LC, liver cirrhosis; ICU, intensive care unit; C-line, central line; Post-op., postoperative state; MCTD, mixed connective tissue disease; HCC, hepatocellular carcinoma; TACE, transarterial chemoembolization; CBD, common bile duct; EST, endoscopic sphincterotomy; BMT, bone marrow transplantation; CTX, cefotaxime; CAZ, ceftazidime; ZOX, ceftizoxime; AMK, amikacin; CIP, ciprofloxacin; IPM, imipenem.