TABLE 1.

Parameter estimates and their standard errorsa

Drugψmax (h−1)ψmin (h−1)κzMIC (μg/ml)MICb (μg/ml)
Ciprofloxacin0.88 ± 0.16−6.5 ± 0.31.1 ± 0.10.017 ± 0.0050.03
Ampicillin0.75 ± 0.21−4.0 ± 0.80.75 ± 0.193.4 ± 1.18.00
Rifampin0.70 ± 0.23−4.3 ± 0.52.5 ± 0.812.0 ± 1.98.00
Streptomycin0.89 ± 0.41−8.8 ± 1.01.9 ± 0.518.5 ± 3.332.00
Tetracycline0.81 ± 0.42−8.1 ± 3.60.61 ± 0.270.67 ± 0.681.00
  • a Calculated using a local quadratic approximation to the nonlinear least squares predictor.

  • b Determined by a twofold dilution protocol.