TABLE 2.

Values of pharmacokinetic parameters obtained with infection models

RegimenPeak concn (μg/ml)Trough concn (μg/ml)Half-life (h)AUC0-24 (μg · h/ml)Cmax SEV concn (μg/g) within 24 h
Daptomycin, 6 mg/kg79.62 ± 0.518.70 ± 0.107.3 ± 0.17755.54 ± 5948 ± 2.83
Nafcillin, 4 g q4h42.88 ± 1.694.99 ± 1.981.45 ± 0.22671.91 ± 789.11 ± 1.25
Linezolid, 600 mg q12h19.07 ± 0.953.58 ± 0.075.05 ± 1.01266.61 ± 2810.98 ± 1.55
Vancomycin, 1 g q12h42.15 ± 1.339.52 ± 0.115.56 ± 0.49597.65 ± 4223.14 ± 0.11
Gentamicin, 1.5 mg/kg q12h6.95 ± 0.160.375 ± 0.542.91 ± 0.0259.50 ± 222.83 ± 0.18