TABLE 2.

Stability of 6-methylidene penem molecules against hydrolysis by renal DHP enzymes from various species

Compound% Hydrolyzeda by 50 μM renal DHP from:
HumanHogMouse
A407487
B2512118
C9.82514
D7.62.019
E327821
F204840
GNTNTNT
TZBb8.0<1<1
  • a Normalized to the level of imipenem hydrolysis, which was set at 100%. NT, not tested.

  • b TZB, tazobactam.