TABLE 3.

Inoculum change over 72 obtained in the SEV modela

AntimicrobialChange in bacterial density (log10 CFU/ml) over 72 h
MSSA 1199 (5 × 105)MRSA 494 (5 × 105)MSSA 1199 (5 × 109)MRSA 494 (5 × 109)
Growth control+4.59+3.78+1.37+0.93
Daptomycin−3.34b−4.36b−6.89b−6.85b
Nafcillin−3.34b−0.47b
Linezolid−0.75b−0.96b−1.36b−2.45b
Vancomycin−3.28b−3.67b−2.38b−3.76b
Gentamicin+0.25−0.62b
Daptomycin + gentamicin−7.28b−5.45b
Nafcillin + gentamicin−4.44b,c
Linezolid + gentamicin−2.87b−2.93b
Vancomycin + gentamicin−3.00b−4.77b,d
  • a Note that positive values indicate regrowth.

  • b P ≤ 0.01 for significance versus growth control.

  • c P ≤ 0.001 for significance of monotherapy versus gentamicin.

  • d P ≤ 0.05 for significance of monotherapy versus gentamicin.