TABLE 4.

Pharmacodynamic properties of antimicrobials tested against MSSA and MRSA at both moderate and high inocula

RegimenT > MIC(albumin) (%)Cmax/MIC(albumin)AUC/MIC(albumin)
MSSAMRSAMSSAMRSAMSSAMRSA
Moderate inoculum
    Daptomycin, 6 mg/kg1591591,5111,511
    Nafcillin, 4 g q4h100100
    Linezolid, 600 mg q12h100100133133
    Vancomycin, 1 g q12h100100149299
    Gentamicin, 1.5 mg/kg q12h12.83.211930
High inoculum
    Daptomycin, 6 mg/kg9.959.959447
    Nafcillin, 4 g q4h0
    Linezolid, 600 mg q12h100100133133
    Vancomycin, 1 g q12h10010075149
    Gentamicin, 1.5 mg/kg q12h6.41.65915